Contemporary synthesis of active pharmaceutical ingredients (APIs) is still largely based on complex, multi-step chemical processes that are costly, energy-intensive, and not always environmentally friendly. In our project, we address these limitations by proposing a modern and more sustainable approach to API synthesis. We focus in particular on compounds with antidepressant and antiepileptic activity, for which global demand is steadily increasing.
We believe that biocatalysis and enzymatic systems offer tremendous development potential and represent the future of modern synthesis technologies. Therefore, our goal is to develop innovative enzymatic systems that enable one-pot reactions using bioengineered and synthetic enzymes. The project includes the design, modification, and immobilization of enzymes to obtain stable, efficient, and reusable biocatalytic systems.
We expect that the developed solutions will contribute to the simplification of API synthesis pathways and to a reduction in the consumption of raw materials and energy. The project is carried out at Poznan University of Technology, which provides excellent research infrastructure and an inspiring, interdisciplinary scientific environment.